Flori Ratna Sari

dr. Flori Ratna Sari, Ph.D

Ph.D, Niigata University of Pharmacy and Applied Life Sciences, Japan

florirsari@uinjkt.ac.id

RIWAYAT PENDIDIKAN
  • 1984–1985 : SD Bruderan Nusa Indah, Kalimantan Barat, Indonesia.
  • 1985–1986 : SD Kanisius, Yogyakarta, Indonesia.
  • 1986-1990 : SD Katolik Sang Timur, Jakarta, Indonesia.
  • 1990–1993 : SMP Negeri 111, Jakarta, Indonesia.
  • 1993–1996 : SMA Negeri 78, Jakarta, Indonesia.
  • 1996–2000 : Fakultas Kedokteran Universitas Indonesia, Jakarta, Indonesia
  • 2000–2002 : Fakultas Kedokteran Universitas Indonesia, Jakarta, Indonesia.
  • 2008–2012 : Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
RIWAYAT PEKERJAAN
  • 2002 – 2003 : Dokter Klinik Medira, Mampang, Jakarta Selatan
  • 2003 – 2006 : Dokter Blue Bird, Cengkareng, Jakarta Barat.
  • 2003 – 2007 : Staf Riset Medical Research Unit, Fakultas Kedokteran Universitas Indonesia.
  • 2006 – sekarang : Dosen Farmakologi Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, UIN Syarif Hidayatullah Jakarta.
  • 2013 – sekarang : Kepala Bidang Pelayanan Laboratorium Biomedik
    Sentra Pelayanan Kesehatan Masyarakat, Fakultas Kedokteran dan Ilmu Kesehatan, UIN Syarif Hidayatullah Jakarta.
  • 2016 – sekarang : Koordinator Bidang Database dan Informasi Lembaga Penelitian dan Pengabdian Masyarakat (LP2M) UIN Syarif Hidayatulah Jakarta.
PENDIDIKAN DAN PEMBELAJARAN
  • BUKU : Flori Ratna Sari. Menjadi relawan : antara emosi dan logika. Dalam Magnitudo 9 (Kumpulan Kisah Inspiratif Pasca Bencana Jepang 2011). Forum Lingkar Pena Jepang. 2011.
  • BUKU : Flori Ratna Sari, Laifa Annisa Hendarmin, Nouval Shahab, Rahmania Diandini. Buku Saku Pembimbing Riset. Program Studi Pendidikan Dokter. FKIK UINJKT. 2012
  • Pembelajaran Aktif Farmakologi :
    1. Metode Diskusi Kasus Pendek : membahas farmakoterapi dalam berbagai aspek melalui kasus.
    2. Metode Games (Farmako Games) : review macam-macam obat dalam bentuk permainan.
      Medical Farmako Games : Dyspepsia. Departemen Kajian Studi dan Profesi BEMJ Pendidikan Dokter FKIK UIN Syarif Hidayatullah Jakarta. 16 September 2013.
PUBLIKASI JURNAL
  • Sari FR, Hendarto H, Muqorobin A, Rosyidi CAH, Amelia E, Hermansyah, Respati L, Maulida N. Insulin leaves (smallanthus sonchifolius) dry extract improves blood glucose and lipid profile in aloxan-induced rat. Asian Jr of Microbiol Biotech Env Sc. 2015; 17 (2) : 405-408.
  • Hendarto H, Sari FR, Muqorobin A, Rosyidi CAH, Amelia E, Hermansyah, Respati L, Maulida N. Cinnamomun cassia extract improves blood glucose and lipid profile in aloxan-induced diabetic rat. Asian Jr of Microbiol Biotech Env Sc. 2015; 17 (2) : 409-414.
  • Soetikno V, Sari FR, Lakshmanan AP, Arumugam S, Harima M, Suzuki K, Kawachi H, Watanabe K. Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway. Mol Nutr Food Res. 2013 57(9):1649-59.
  • Soetikno V, Sari FR, Sukumaran V, Lakshmanan AP, Harima M, Suzuki K, Kawachi H, Watanabe K. Curcumin decreases renal triglyceride accumulation through AMPK-SREBP signaling pathway in streptozotocin-induced type 1 diabetic rats. J Nutr Biochem. 2013;24(5):796-802.
  • Soetikno V, Sari FR, Sukumaran V, Lakshmanan AP, Mito S, Harima M, Thandavarayan RA, Suzuki K, Nagata M, Takagi R, Watanabe K. Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: possible involvement of PKC-MAPK signaling pathway. Eur J Pharm Sci. 2012 9;47(3):604-14.
  • Arumugam S, Thandavarayan RA, Veeraveedu PT, Ma M, Giridharan VV, Arozal W, Sari FR, Sukumaran V, Lakshmanan A, Soetikno V, Suzuki K, Kodama M, Watanabe K. Modulation of endoplasmic reticulum stress and cardiomyocyte apoptosis by mulberry leaf diet in experimental autoimmune myocarditis rats. J Clin Biochem Nutr. 2012;50(2):139-44.
  • Arumugam S, Thandavarayan RA, Veeraveedu PT, Nakamura T, Arozal W, Sari FR, Giridharan VV, Soetikno V, Palaniyandi SS, Harima M, Suzuki K, Nagata M, Kodama M, Watanabe K. Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy. J Cell Mol Med. 2012;16(9):2176-85.
  • Thandavarayan RA, Giridharan VV, Sari FR, Arumugam S, Veeraveedu PT, Pandian GN, Palaniyandi SS, Ma M, Suzuki K, Gurusamy N, Watanabe K. Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodeling process via modulation of MAPK/NF-ĸB signaling pathways after streptozotocin-induced diabetes mellitus. Cell Physiol Biochem. 2011;28(5):911-22.
  • Arumugam S, Thandavarayan RA, Arozal W, Sari FR, Giridharan VV, Soetikno V, Palaniyandi SS, Harima M, Suzuki K, Nagata M, Tagaki R, Kodama M, Watanabe K. Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signalling. Free Radic Res. 2012;46(2):154-63.
  • Arumugam S, Thandavarayan RA, Palaniyandi SS, Giridharan VV, Arozal W, Sari FR, Soetikno V, Harima M, Suzuki K, Kodama M, Watanabe K. Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis. Toxicology. 2012 27;291(1-3):139-45.
  • Sari FR, Arozal W, Watanabe K, Harima M, Veeravedu PT, Thandavarayan RA, Suzuki K, Arumugam S, Soetikno V, Kodama M. Carvedilol attenuates inflammatory-mediated carditoxicity in daunorubicin-induced rats. Pharmaceuticals. 2011;4:551-566.
  • Arozal W, Sari FR, Watanabe K, Arumugam S, Veeraveedu PT, Ma M, Thandavarayan RA, Sukumaran V, Lakshmanan AP, Kobayashi Y, Mito S, Soetikno V, Suzuki K. Carvedilol-Afforded Protection against Daunorubicin-Induced Cardiomyopathic Rats In Vivo: Effects on Cardiac Fibrosis and Hypertrophy. ISRN Pharmacol. 2011;2011:430549.
  • Soetikno V, Watanabe K, Sari FR, Harima M, Thandavarayan RA, Veeraveedu PT, Arozal W, Sukumaran V, Lakshmanan AP, Arumugam S, Suzuki K. Curcumin attenuates diabetic nephropathy by inhibiting PKC-α and PKC-β1 activity in streptozotocin-induced type I diabetic rats. Mol Nutr Food Res. 2011;55(11):1655-65.
  • Watanabe K, Thandavarayan RA, Harima M, Sari FR, Gurusamy N, Veeraveedu PT, Mito S, Arozal W, Sukumaran V, Laksmanan AP, Soetikno V, Kodama M, Aizawa Y. Role of differential signaling pathways and oxidative stress in diabetic cardiomyopathy. Curr Cardiol Rev. 2010;6(4):280-90.
  • Lakshmanan AP, Thandavarayan RA, Palaniyandi SS, Sari FR, Meilei H, Giridharan VV, Soetikno V, Suzuki K, Kodama M, Watanabe K. Modulation of AT-1R/CHOP-JNK-Caspase12 pathway by olmesartan treatment attenuates ER stress-induced renal apoptosis in streptozotocin-induced diabetic mice. Eur J Pharm Sci. 2011 18;44(5):627-34.
  • Lakshmanan AP, Thandavarayan RA, Watanabe K, Sari FR, Meilei H, Giridharan VV, Sukumaran V, Soetikno V, Arumugam S, Suzuki K, Kodama M. Modulation of AT-1R/MAPK cascade by an olmesartan treatment attenuates diabetic nephropathy in streptozotocin-induced diabetic mice. Mol Cell Endocrinol. 2012;348(1):104-11.
  • Sari FR, Widyantoro B, Thandavarayan RA, Harima M, Lakshmanan AP, Zhang S, Muslin AJ, Suzuki K, Kodama M, Watanabe K. Attenuation of CHOP-mediated myocardial apoptosis in pressure-overloaded dominant negative p38α mitogen-activated protein kinase mice. Cell Physiol Biochem. 2011;27(5):487-96.
  • Soetikno V, Sari FR, Veeraveedu PT, Thandavarayan RA, Harima M, Sukumaran V, Lakshmanan AP, Suzuki K, Kawachi H, Watanabe K. Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy. Nutr Metab (Lond). 2011;8(1):35.
  • Lakshmanan AP, Watanabe K, Thandavarayan RA, Sari FR, Meilei H, Soetikno V, Arumugam S, Giridharan VV, Suzuki K, Kodama M. Curcumin attenuates hyperglycaemia-mediated AMPK activation and oxidative stress in cerebrum of streptozotocin-induced diabetic rat. Free Radic Res. 2011 Jul;45(7):788-95.
  • Watanabe K, Sukumaran V, Veeraveedu PT, Thandavarayan RA, Gurusamy N, Ma M, Arozal W, Sari FR, Lakshmanan AP, Arumugam S, Soetikno V, Rajavel V, Suzuki K. Regulation of inflammation and myocardial fibrosis in experimental autoimmune myocarditis. Inflamm Allergy Drug Targets. 2011;10(3):218-25. Review.
  • Lakshmanan AP, Watanabe K, Thandavarayan RA, Sari FR, Harima M, Giridharan VV, Soetikno V, Kodama M, Aizawa Y. Telmisartan attenuates oxidative stress and renal fibrosis in streptozotocin induced diabetic mice with the alteration of angiotensin-(1-7) mas receptor expression associated with its PPAR-γ agonist action. Free Radic Res. 2011 May;45(5):575-84.
  • Sari FR, Watanabe K, Widyantoro B, Thandavarayan RA, Harima M, Kodama M, Aizawa Y. Sex differences play a role in cardiac endoplasmic reticulum stress (ERS) and ERS-initiated apoptosis induced by pressure overload and thapsigargin. Cardiovasc Pathol. 2011;20(5):281-90.
  • Sari FR, Watanabe K, Widyantoro B, Thandavarayan RA, Harima M, Zhang S, Muslin AJ, Kodama M, Aizawa Y. Partial inactivation of cardiac 14-3-3 protein in vivo elicits endoplasmic reticulum stress (ERS) and activates ERS-initiated apoptosis in ERS-induced mice. Cell Physiol Biochem. 2010;26(2):167-78.
  • Thandavarayan RA, Watanabe K, Sari FR, Ma M, Lakshmanan AP, Giridharan VV, Gurusamy N, Nishida H, Konishi T, Zhang S, Muslin AJ, Kodama M, Aizawa Y. Modulation of doxorubicin-induced cardiac dysfunction in dominant-negative p38α mitogen-activated protein kinase mice. Free Radic Biol Med. 2010;49(9):1422-31.
  • Sari FR, Watanabe K, Thandavarayan RA, Harima M, Zhang S, Muslin AJ, Kodama M, Aizawa Y. 14-3-3 protein protects against cardiac endoplasmic reticulum stress (ERS) and ERS-initiated apoptosis in experimental diabetes. J Pharmacol Sci. 2010;113(4):325-34.
  • Sari FR, Ekayanti F. Pengetahuan dan sikap mengenai kesehatan reproduksi wanita pada peserta training kesehatan reproduksi remaja SMP dan SMU seJakarta Timur, Jakarta Islamic Centre, 13 Agustus 2006. Medika Islamika 2006;4(1):12-18.
  • Ekayanti F, Sari FR. Perubahan pengetahuan tentang kesehatan reproduksi wanita pada peserta training kesehatan reproduksi remaja. Medika Islamika 2006;4(2):93-99.
KARYA ILMIAH DALAM KONFERENSI
  • Hendarto H, Sari FR, Adhyanto C. Cinnamomum burmannii improves serum insulin level in the normal obese subjects : preliminary study. 1st International Conference on Health Sciences. Gajah Mada University. 2016.
  • Sari FR, Soetikno V, Arozal W, thandavarayan RA, Arumugam S, Harima M, Watanabe K. Free radical scavenger memperbaiki jantung diabetes melalui pengaturan stress retikulum endoplasma. Seminar Nasional PSPD Expo. Universitas Islam Negeri Syarif Hidayatullah. 2015.
  • Sari FR, Thandavarayan RA, Widyantoro B, Emoto N, Giridharan VV, Harima M, Zhang S, Muslin JA, Sukumaran V, Soetikno V, Lakshmanan AP, Arumugam S, Watanabe K. Exacerbation of endoplasmic reticulum stress-related maladaptive cardiac remodeling in pressure-overloaded dominant negative 14-3-3η mice. The 76th Annual Scientific Meeting of the Japanese Circulation Society. March 2012.
  • Sari FR, Watanabe K, Widyantoro B, Thandavarayan RA, Harima M, Sukumaran V, Soetikno V, Lakshmanan AP, Arumugam S, Zhang S, Muslin AJ. Endoplasmic reticulum stress induces cardiomyocyte apoptosis during pathological cardiac hypertrophy through the p38 MAPK pathway. The 28th Annual Meeting of the International Society for Heart Research (ISHR) Japanese section. 2011.
  • Sari FR, Watanabe K, Thandavarayan RA, Harima M, Sukumaran V, Soetikno V, Lakshmanan AP, Arumugam S. Free radical scavenger protects against complications in heart and kidney by attenuating oxidative and endoplasmic reticulum stress in diabetic mice. The 10th Continuing Professional Development Series: Diabetes Asia 2011.
  • Sari FR, Watanabe K, Thandavarayan RA, Harima M, Sukumaran V, Soetikno V, Lakshmanan AP, Arumugam S, Zhang S, Muslin AJ. Protective roles of 14-3-3 protein against endoplasmic reticulum stress (ERS) and ERS-initiated apoptosis in diabetic heart. The 10th Continuing Professional Development Series: Diabetes Asia 2011.
PENGHARGAAN PENELITIAN
  • National Diabetes Institute (NADI) Malaysia 2011, Young Investigator Award (Second Place), Free radical scavenger protects against complications in heart and kidney by attenuating oxidative and endoplasmic reticulum stress in diabetic mice 2011. Award : 3000 RM.
  • Japanese Circulation Society Japan 2012, Young Investigator Award (Second Place)
    Exacerbation of endoplasmic reticulum stress-related maladaptive cardiac remodeling in pressure-overloaded dominant negative 14-3-3 eta mice. Award : 100.000 ¥.
  • Novell dan Perhimpunan Dokter Spesialis Penyakit Dalam Indonesia 2013
    Scientific Grants Award (First Place). Pengaruh pemberian ekstrak Cinnamomum cassia terhadap Indeks Massa Tubuh dan Kadar Insulin pasien obesitas, Award : Rp 100.000.000,-
  • Fakultas Kedokteran dan Ilmu Kesehatan, UIN Syarif Hidayatullah 2015
    Dosen Teladan Program Studi Pendidikan Dokter
  • Webomatric, 2016 Peringkat 61 dari 100 Peneliti Terbaik Indonesia